1st Research Project:
Functional genomics in biological and biomedical
prof. dr hab. Chandra Pareek
Functional genomics is a field of molecular and
theoretical biology which is focused on analyzing genomes of various
organisms, from bacteria to humans. The main goal of
genomics is to decrypt the sequence of the genetic material and map the
genomes, as well as to study relations and interactions between genes.
The research will be performed in four packages:
Medical biotechnology – human genomics
Modern methods of molecular biology, such as sequencing, genotyping and
gene expression profiling, will be used. The projects will be
multi-center and will require collaboration of physicians, geneticists
and bioinformaticians. They will be focused on the development of
genetic pictures of human diseases, cancers in particular. Advanced
genetic studies will be done, resulting in better diagnostics,
pathogenesis and treatment response monitoring and determination of the
risk of recurrence. The analyzes will be of practical importance, as the
results will serve to assess individual genetic risk factors and develop
That part of genomics will be carried out mainly on gene expression
analysis and the development of biomarker utilizing advanced Next
Generation Genome Sequencing technologies and bioinformatics (www.genomics-lab.com).
It will further focus on the integration of genomic and transcriptomic
technologies towards translational cancer research (TCR).
Genes responsible for economically important traits (stress resistance,
yield) will be sought for both in model plants, such as Arabidopsis
thaliana and Nicotiana tabacum, and in crops (tomato or sugar beet).
This will allow obtaining improved crop varieties.
Bacterial genomics and metagenomics
Bacterial populations from various environments, such as soils, fresh
and marine waters and human gastrointestinal tract, will be analyzed.
Genes that allow removal of toxic compounds from the environment will be
looked for. The genes could be used in bioremediation.
The planned projects will make it possible to obtain genes that encode
enzymes engaged in the synthesis of novel secondary metabolites (e.g.
Microbial biodiversity in soils and waters will also be assessed to
check human influence on the environment. The relation between bacterial
population composition in human gastrointestinal tract and diseases (cancers
in particular) will be studied as well.